Learn all preparation and usage instructions in the product package. Read the Patient Information Leaflet available from your pharmacist before you start using salmeterol/fluticasone and each time you get a refill. Refer to the illustrated directions provided by the manufacturer for directions on how to use this device. If any of the information is unclear, consult your doctor or pharmacist.

Before you use your inhaler device for the first time, release 2 puffs into the air to check that it is working properly.

Shake the inhaler well before each dose. Inhale this medication by mouth, usually twice daily in the morning and evening (12 hours apart), or use as directed by your doctor. The dosage is based on your medical condition and response to therapy. Use this medication regularly to receive the most benefit from it. To help you remember, use it at the same times each day. Do not use it more often than prescribed since this may increase the risk of side effects.

Gargle and rinse your mouth with water after using this medication to help prevent dryness and mouth infections (e.g., thrush) and relieve throat irritation. Do not swallow the rinse water.

Clean the inhaler at least 1 time weekly as directed in the patient instructions.

Do not stop taking this medication or change your dose without consulting your doctor. Some conditions may become worse when the drug is suddenly stopped. Your dose may need to be gradually decreased.

If you have been using a quick-relief inhaler (e.g., salbutamol, albuterol) on a regular daily schedule (such as 4 times daily), you must stop this schedule and only use it as needed for sudden shortness of breath/asthma attacks. Consult your doctor for details.

If this medication stops working well, or you need to use your quick-relief inhaler more often than usual (4 or more puffs for 2 or more days in a row, or use of more than 1 inhaler every 8 weeks), seek immediate medical attention. It may be a sign of worsening asthma, which is a serious condition.

Learn which of your inhalers you should use every day and which you should use if your breathing suddenly worsens. Ask your doctor what to do if you have worsening cough or shortness of breath, wheezing, increased sputum, or worsening peak flow meter readings. Learn when you can self-medicate and when you should get medical help right away.

It may take 1 week or longer before the full benefit of this drug takes effect. Inform your doctor if your condition persists or worsens.